My current research interest lies in a group of genes, which encode splicing factors, that are recurrently mutated in cancers.  I am interested to understand the functional significance of these mutant splicing factors.  For example, how mutant splicing factors impact pre-mRNA splicing?  How they are selected during carcinogenesis?  What vulnerability cancer cells have when they harbor splicing factor mutations?  To address these questions, I have built isogenic human lung cell lines and mouse models for one such mutation, the Ser to Phe missense mutation at codon 34 for the splicing factor gene U2AF1.  These experimental models have provides insights in understanding the role of mutant U2AF1 in cancer.  Outside of the lab, I enjoy cooking gourmet food and following a number of sports, including soccer and American football.