Prospects for understanding and exploiting the consequences of hyperactivation lethality.

Shaw K, Bernards R, Stegmaier K, Varmus H, Sellers WR.

Trends Cancer. 2025 Jul;11(7):619-628. doi: 10.1016/j.trecan.2025.04.009. Epub 2025 May 19. PMID: 40393917

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Gardner EE, Earlie EM, Li K, Thomas J, Hubisz MJ, Stein BD, Zhang C, Cantley LC, Laughney AM, Varmus H.

Science. 2024 Feb 9;383(6683):eadj1415. doi: 10.1126/science.adj1415. Epub 2024 Feb 9. PMID: 38330136; PMCID: PMC11155264.

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase

Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H.

Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. PMID: 38743625; PMCID: PMC11127050.

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.

 Chen HJ, Poran A, Unni AM, Huang SX, Elemento O, Snoeck HW, Varmus H.

 J Exp Med. 2019 Mar 4;216(3):674-687. doi: 10.1084/jem.20181155. Epub 2019 Feb 8.

 PMID: 30737256

 Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells.

 Unni AM, Harbourne B, Oh MH, Wild S, Ferrarone JR, Lockwood WW, Varmus H.

 Elife. 2018 Nov 26;7. pii: e33718. doi: 10.7554/eLife.33718.

 PMID: 30475204

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.

Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H.

Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907.

PMID: 26047463

Rescuing US biomedical research from its systemic flaws.

Alberts B, Kirschner MW, Tilghman S, Varmus H.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5773-7. doi: 10.1073/pnas.1404402111. Epub 2014 Apr 14.

PMID: 24733905

Three decades of Wnts: a personal perspective on how a scientific field developed.

Nusse R, Varmus H.

EMBO J. 2012 Jun 13;31(12):2670-84. doi: 10.1038/emboj.2012.146. Epub 2012 May 22. Review.

PMID: 22617420

The Art and Politics of Science.

Varmus H.

New York: W.W. Norton & Company; 2009.

PMID: 24696889